These genetic correlations generally remained consistent after conditioning POU on risk-taking behavior, nicotine, and cannabis use disorders (Supplementary Tables 12, 13, and 14, respectively; Fig. 4). These associations were also broadly consistent when we conditioned on pain (Supplementary Tables 16) and OUD (Supplementary Tables 17). Intriguingly, when we corrected for alcohol dependence some of the associations increased, particularly with OUD and opioid dependence, cannabis use disorder, and depressive symptoms, whereas some associations dramatically decreased, such as nicotine dependence as measured via FTND (Supplementary Table 15) [42].
