explain risk for the particular subgroup to which that individual belongs. We assessed the value of combining information from the candidate gene panel with family history, as family history and the candidate gene sum score were not correlated (r = 0.021, n = 1081 p = 0.490). We found that the AUC for family history increased nominally from 0.686 to 0.690 in COGA after adding the candidate gene sum score. This suggests that there was negligible additional information when the candidate gene panel is added to family history information.
