Study participants of self-reported European ancestry recruited in the Raleigh-Durham metropolitan area by advertising and word of mouth provided informed consents for studies of smoking cessation, averaged age 44 and were 45% female. These participants reported an average of 25 years of smoking, displayed initial Fagerstrom Test for Nicotine Dependence (FTND) [5] scores that averaged 6.4 and provided screening carbon monoxide levels that averaged 34.7. Participants received oral mecamylamine (10 mg/day) and either active (21 mg/24 h) or placebo nicotine skin patches for two weeks before the target quit-smoking date. After the quit-date, participants were randomly assigned to groups that received mecamylamine (10 mg/day) vs matching placebo and 21 mg/24 h vs 42 mg/24 h nicotine skin patch doses to test how mecamylamine might improve effectiveness of nicotine replacement therapy. Behavioral support and self-help quitting manuals were also provided. Fifty-five study participants reported continuous abstinence from smoking when assessed 6 weeks after the quit date. 79 participants were not abstinent at the 6 week time point. Data from these individuals was compared to data from 320 control study participants of
