Our results were highly concordant with ASPS. BMI was significantly associated with T2* in amygdala (averaged across left and right: beta=-0.07, -log10Puncorrected=3.9) and hippocampus (beta=-0.15, -log10Puncorrected=17.0; for comparison, FDR correction would result in PFDR<10-10). Individual subcortical BMI associations are shown in Fig 8b. In accordance with our hypothesis, the signs of regression betas are universally negative with T2* from UK Biobank data. Associations with T2* were found for age in thalamus, caudate and putamen (see Fig 8c) and for smoking status in caudate, putamen and right pallidum (beta ranging from -0.03 to -0.1). Association of T2* with sex was only found in right amygdala, and no association was found for hypertension.
