The first paper in this issue, by Luczak et al. 3, reviews the prevalence rates of addictive behaviors and their co-occurrences in U.S. racial/ethnic groups and their implications for genetics research. The next two papers consider the role of environmental factors in association with genetic factors and race/ethnicity. Agrawal et al. 4 examine the influence of religious involvement on the alcohol use behaviors of African American and White younger adult women. Then Chartier et al. 5 survey a larger set of environmental influences for African Americans, Asians, Latinos, and American Indians for investigation in gene-environment (G-E) studies.