The weakest evidence for association was seen for rs9300039 that was listed by the FUSION investigators as a confirmed susceptibility locus for type 2 diabetes [10]. The random effects summary odds ratio yielded a mere p = 0.015, as compared with p = 4.3×10−7 by Mantel-Haenszel calculations, and there was very large between-study heterogeneity (75%). Heterogeneity might reflect in part the different tag polymorphisms used in the other two GWA investigations [11], [13]. Even so, the evidence remains very weak. Fine mapping and more extensive data would be required for this locus before a concrete claim can be made that it confers susceptibility to type 2 diabetes.
