used in previous studies(26–29) including the largest MDD GWAS available to date by the Psychiatric Genomics Consortium(4). Of note, 1,452 cases and 99 controls from the current study were previously included in the larger (1,943 cases, 1,807 controls) GAIN-MDD dataset. In GAIN, cases and controls were genotyped on a different platform (Perlegen-Affymetrix 5.0) as compared to the current study (Affymetrix 6.0).