While our genome-scan identified no definitive associations between SNPs and schizophrenia risk, SNPs in the ADAMTSL3 gene were the most strongly associated. One of the ADAMTSL3 SNPs is clearly functional and influences the proportion of two alternative transcript species. Nevertheless, study of additional cohorts strongly suggested that ADAMTLS3 is not related to schizophrenia risk and that functional evidence should not be used to strengthen claims for modestly associated variants.
