have found that the LL genotype is associated with a low level of response to alcohol (Hu et al., 2005; Schuckit et al., 1999), indicating that more work is needed. To our knowledge, no studies have directly assessed level of alcohol response as a potential mediator in the relationship between genes and behavior. Thus, we aimed to determine whether level of response to alcohol may be a potential mechanism through which 5-HTTLPR predicts later alcohol outcomes.
