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Chunk #11 — 2. MOLECULAR ADAPTATIONS ACCOMPANYING EARLY RESPONSE AND LONG-TERM ADAPTATIONS IN THE ADDICTED BRAIN

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Gene expression in the addicted brain.
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cocaine-induced transcription changes in rat NAc and cocaine seeking behavior (Chandrasekar & Dreyer, 2010). In addition, there was also convergent evidence that chronic cocaine exposure alters expression of genes involved in RNA processing, including significant alteration in the expression of genes encoding RNA-binding and processing proteins and enrichment of differentially expressed small nucleolar (sno) RNA genes, which are involved in both ribosomal RNA and mRNA processing (Kishore & Stamm, 2006).