cocaine-induced transcription changes in rat NAc and cocaine seeking behavior (Chandrasekar & Dreyer, 2010). In addition, there was also convergent evidence that chronic cocaine exposure alters expression of genes involved in RNA processing, including significant alteration in the expression of genes encoding RNA-binding and processing proteins and enrichment of differentially expressed small nucleolar (sno) RNA genes, which are involved in both ribosomal RNA and mRNA processing (Kishore & Stamm, 2006).