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Chunk #2 — Methods — Multi-cohort data collection

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CommonMind Consortium provides transcriptomic and epigenomic data for Schizophrenia and Bipolar Disorder.
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This data release of the CommonMind Consortium9 is composed of 4 separate brain banks (Supplementary Fig. 1). Assembling individuals from multiple sites enables larger sample size; enables cross-site replication of findings; and reduces the effect of variables in sample collection, specimen preservation and generation of molecular data in any single site. The brain banks include 501 control individuals, 353 individuals with schizophrenia, as well as 132 individuals with either affective disorder, bipolar disorder or an undetermined disorder (Table 1). We note that age, percent male and postmortem interval varies substantially across cohorts.Table 1Multi-cohort demographics. Samples are control, undetermined (Other) or from individuals with schizophrenia (SCZ), affective disorders (AFF) or bipolar disorder (BP).DiagnosisStudyBrain BankNAge (Years)PMI% MaleControlCMCMSSM16574.3 ± 17.510.851.5Penn3767.4 ± 15.513.448.6Pitt8348.0 ± 14.01972.3CMC_HBCCNIMH-HBCC21635.3 ± 20.42971.3SCZCMCMSSM14772.8 ± 12.923.768.0Penn5779.2 ± 11.713.538.6Pitt5547.8 ± 13.120.276.4CMC_HBCCNIMH-HBCC9449.9 ± 13.83766.0AFF/BPCMCMSSM2263.4 ± 16.015.732.8Penn0Pitt3545.5 ± 12.220.557.1CMC_HBCCNIMH-HBCC7142.6 ± 14.429.867.6OtherCMC_HBCCNIMH-HBCC431.5 ± 19.730.0100.0Mean age and mean postmortem interval (PMI) displayed (±s.d.).