Chunk #34 — DISCUSSION

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CHRNB3 is more strongly associated with Fagerström test for cigarette dependence-based nicotine dependence than cigarettes per day: phenotype definition changes genome-wide association studies results.

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It is interesting to note that the FTCD phenotype is strongest as a dichotomous variable, and the highly significant test for proportional odds indicates that the relationship between nicotine dependence and this region is a threshold phenomenon. This suggests that the relationship between CHRNB3 and smoking behavior may be more related to specific component of nicotine dependence rather than smoking quantity.