In this study we evaluated mRNA and miRNA expression patterns in the NAc of 18 AD cases and 18 matched controls and perform gene co-expression network analysis to identify gene networks associated with AD. We then integrated gene expression with genotypic data to identify eQTLs that impact the expression of network hub genes in NAc, and provide evidence that these eQTLs are enriched for AD GWAS signals in the Collaborative Study on the Genetics of Alcoholism (COGA) sample.
