Data were analyzed using SPSS version 19.0. Demographic and drug use variables, and lifetime and current prevalence of DSM-IV-TR diagnoses (Axis I) were calculated and presented in cross-tabulations. Data were presented by three groups based on MA-; heroin-; MA and heroin co-dependence. Simple descriptive statistics were expressed as “mean and standard deviation” for continuous variables; “frequency and percentage” for categorical variables. Differences in demographic and drug use variables among groups were tested using t test, ANOVA test or Pearson’s χ2 test. Furthermore, lifetime and current prevalence of psychiatric disorders and SUDs between groups were compared using binary logistic regression analysis between each two groups. Each disorder was entered as the dependent variable with the “Enter” method after the potentially confounding effects of variables that significantly differed in univariate analyses had been controlled for. To adjust for multiple comparisons the significance level was set to p < 0.01 (two-tailed) for all comparisons in the study.