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Chunk #11 — Developmental Trajectories: The Journey as Well as the Destination — Attention-Deficit/Hyperactivity Disorder

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Structural MRI of pediatric brain development: what have we learned and where are we going?
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Cross-sectional anatomical imaging studies of ADHD consistently point to involvement of the frontal lobes (Castellanos et al., 2002), parietal lobes (Sowell et al., 2003), basal ganglia (Castellanos and Giedd, 1994), corpus callosum (Giedd et al., 1994), and cerebellum (Berquin et al., 1998). Imaging studies of brain physiology also support involvement of right frontal-basal ganglia circuitry with a powerful modulatory influence from the cerebellum (see Giedd et al., 2001, for review).