Chunk #53 — METHODS — Gene-based association and tissue-specific gene expression.

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Genome-wide analyses of ADHD identify 27 risk loci, refine the genetic architecture and implicate several cognitive domains.

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Enrichment in h2SNP of ADHD-associated variants located in or close to genes expressed in specific brain regions was estimated using LDSC-SEG30. Annotations indicating specific expression in 13 brain regions from the GTEx gene expression database were downloaded from https://alkesgroup.broadinstitute.org/LDSCORE/LDSC_SEG_ldscores/.