suicide, as will be described later. In contrast, multiple animal studies have shown that the blockade of CB1R signaling in rodents results in anhedonia-like behavior [91], and heightened levels of basal anxiety [92,93,94], and in general, an increased tendency to develop a passive coping response to stress [95,96]. In these latter studies, an increase in the hypothalamic–pituitary-adrenal axis (HPA axis) activity under both basal conditions and following exposure to stress was also observed [86,95,96,97].
