In the secondary meta-analysis combining all 1496 TS cases and 5249 controls (European ancestry samples plus 211 cases and 285 controls from the Latin American CVCR/ANT samples), the strongest association was again found in rs7868992 within COL27A1 on 9q32 (combined p= 2.94 × 10−8; Table S5, Figures S9c,S14). Examination of an LD-pruned set of top SNPs from the primary meta-analysis (412 SNPs with p<1 × 10−3) found a slight, but non-significant increase in the number of SNPs with the same direction of effect in the CVCR/ANT analysis (223/412, p=0.052, one-sided binomial sign test; Tables S2,S3).
