We tested for enrichment of anthropometric trait SDEs (ASDEs) among SNPs nominally associated with OCD (p<10−3) in (a) the combined male/female analysis, (b) the sex-stratified analyses, and (c) the OCD SDEs. ASDEs were defined using the approach described in (Mitra et al. 2016) (Z-score p<=10−3) for several anthropomorphic traits from the GIANT consortium (Randall et al. 2013): weight, height, body mass index (BMI), hip circumference (HIP), HIP adjusted for BMI (HIPadjBMI), waist circumference (WC), WC adjusted for BMI (WCadjBMI), waist-to-hip ratio (WHR), and WHR adjusted for BMI (WHRadjBMI) resulting in a total of 12,006 unique ASDEs identified across GIANT phenotypes. We determined the overlap of ASDEs with each OCD subset (Supplementary Figure 9), as well as with 1000 matching SNP sets for each of the OCD subsets. An empirical enrichment p-value was calculated as the proportion of null randomized sets in which the overlap matched or exceeded the observed overlap using the OCD associated SNPs.
