Chunk #47 — Results — Mecp2 isoform-specific expression correlates with DNA methylation at the Mecp2 regulatory elements

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Decitabine alters the expression of Mecp2 isoforms via dynamic DNA methylation at the Mecp2 regulatory elements in neural stem cells.

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Taken together, these results show a strong (r > 0.8, P <0.05) and dynamic (positive or negative) relationship between DNA methylation at the Mecp2 REs and expression of Mecp2 isoforms depending on the different stages of NSC differentiation. Therefore, these results implicate a possible dynamic role of DNA methylation at the Mecp2 REs in regulating Mecp2 isoform-specific expression.