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Chunk #18 — Results — Linkage disequilibrium score regression (LDSC)

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Significant Locus and Metabolic Genetic Correlations Revealed in Genome-Wide Association Study of Anorexia Nervosa.
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Notable significant genetic correlations between anorexia nervosa and psychiatric traits and disorders included neuroticism (rg =0.39, SE=0.14, p=4.4×10−3), schizophrenia (rg =0.29, SE=0.07, p=4.4×10−5), and results from a meta-analysis across psychiatric phenotypes (rg =0.22, SE=0.07, p=3.4×10−3). Genetic correlations between anorexia nervosa and educational phenotypes such as years of education (rg =0.34, SE=0.08, p=5.2×10−6) and attending college (rg =0.30, SE=0.07, p=4.4×10−5) were also positive and significant. Obsessive compulsive disorder GWAS data were unavailable to us but a previous analysis reported a positive rg with anorexia nervosa of 0.53 (SE=0.11, SE=0.13, p=5.5×10−6) (24).