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Chunk #69 — 4. Discussion

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Olfaction in the psychosis prodrome: electrophysiological and behavioral measures of odor detection.
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CHR patients and healthy controls as a group showed highly comparable levels of odor identification and odor thresholds, as well as odor detection performance and olfactory ERPs. While the current findings for odor identification are in disagreement with prior reports (Brewer et al., 2003; Kamath et al., 2011; Woodberry et al., 2010), there are no previous studies in CHR patients measuring odor thresholds, odor detection or olfactory ERPs. However, there was considerable variability in these measures of olfactory function among patients, and three CHR patients who later developed psychosis had marked reductions of odor thresholds, odor detection performance and olfactory N1 and P2, which further underscores the potential value of olfactory measures for predicting transition to psychosis in high-risk individuals (Corcoran et al., 2010; Turetsky et al., 2012). In agreement with previous studies in patients with psychosis (Brewer et al., 2001; Corcoran et al., 2005; Good et al., 2006; Malaspina & Coleman, 2003; Moberg et al., 2006), negative symptoms in CHR patients were associated not only with poorer odor identification and right odor thresholds, but also showed a strong association