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Chunk #17 — RESULTS — GWAS results — Gene-based association

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Genome-wide association study identifies a novel locus for cannabis dependence.
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There was no evidence for enrichment of association within genes for cannabis dependence diagnosis. (Supplemental Table S6); However, for symptom count, MEI1, on chromosome22, was associated at a gene-level (p=2.55E-6; Supplemental Table S7). Several other genes with SNPs of nominal significance clustered in this chromosomal region (Figure S3 for chromosome 22 regional association plot).