SNP-based heritability was estimated in European ancestries using SBayesS14 at 8.4% (SE 0.07%) on the liability scale (assuming lifetime MD risk of 15%) similar to prior estimates.4,7 Analyses of the genetic architecture using SBayesS estimated a polygenicity of 6% and selection parameter of −0.54. Compared with previously reported estimates for 155 traits, MD has a relatively higher polygenicity, but its associated variants are under weaker negative selection.14
