We also compared heritability across ancestries using the GCTA GREML method, which allows analysis of admixed populations when individual genotypes are available. GCTA estimates in the smaller EUA data remained similar to LDSC on the full data (Table 2). Heritability in AFA was comparable to estimates for EUA in the overall sample and when stratified by sex.Table 2Comparison of heritability between European (EUA) and African ancestry (AFA) studiesSample N N 10% prev30% prev50% prevCasesControls h 2 SNP 95% CI h 2 SNP 95% CI h 2 SNP 95% CIp-value All EUA935425,1750.040.02–0.060.050.02–0.080.050.02–0.081.3 × 10−4 AFA316394590.02−0.04 to 0.090.03−0.06 to 0.120.04−0.06 to 0.130.22744 Men EUA441217,3800.02−0.02 to 0.050.02−0.02 to 0.070.03−0.03 to 0.080.15951 AFA119543610.02−0.14 to 0.180.03−0.2 to 0.250.03−0.21 to 0.270.41127 Women EUA468958740.080.03–0.130.120.05–0.190.130.05–0.204.0 × 10−4 AFA176144350.12−0.01 to 0.250.17−0.01 to 0.350.18−0.01 to 0.380.028Analyses are performed using GCTA in both sexes and for men and women separately and include all subjects used in the EUA and AFA GWAS with access to individual-level genotype data. Number of SNPs ranges from 4,071,335 to 4,863,146.P-value is testing if h2SNP is different from zero and applies to all prevalencesh2SNP mean SNP-based heritability, 95% CI 95% confidence interval, prev prevalence
