In summary, our work contributes to the use of polygenic risk for a further understanding of PTSD risk and its underlying mechanisms, whereas also identifying areas of needed future research. Overall, these findings showed that PRS, in addition to being a powerful prognostic tool, is useful in unravelling disease etiology and mechanisms, which, in turn, will enable more personalized and novel intervention strategies. As more well-powered genetic studies become available in the near future, together with advances in whole-genome and exome sequencing, accuracy, and insight obtained from such analyses will become even more precise and useful clinically.
