We also looked up the results for the top TD SNPs in our previously published CD [18] and OD [13] GWAS of case-control status where controls were exposed to cocaine or opioids. There was modest evidence for association of each TD GWS variant identified with risk of dependence (not TD) on the respective substances, although not at the GWS level. Rs61835088 (P = 0.007) and rs2825295 (P = 0.001) were associated with binary CD diagnosis, and rs4860439 (P = 1.11 × 10−6) and rs7032521 (4.10 × 10−7) with OD diagnosis. The OPRM1 OD variant (rs1799971) identified by Polimanti et al. [16] and Zhou et al. [19] was nominally associated with OD TD in Yale-Penn EAs (P = 0.05).
