Examples of other candidate genes with experimentally derived functional information that are hypothesized to function within the binge-intoxication domain including (see Table 2): (serotonin type 2B receptor [HTR2B]) implicated in impulsivity, anti-social personality, and aggression (Bevilacqua et al., 2010; Tikkanen et al., 2015); (mu-opioid receptor [OPRM1]) implicated in reward learning, greater subjective reinforcement from alcohol consumption, greater alcohol-cue and stress reactivity; cortisol stress response, and treatment response to naltrexone (Lovallo et al., 2015; Ray et al., 2012). The dopamine receptors, [DRD2 and DRD4] implicated in reward learning, modulation of neural processes underlying response inhibition, and impulsivity (Filbey et al., 2012; Savitz et al., 2013).
