Initially, researchers focused on modeling monogenetic neuropsychiatric disorders, including Rett and Fragile X syndromes37 (reviewed elsewhere38, 39). However, recent reports highlight the power of using iPSC-derived neurons to model psychiatric disorders from patients with non-monogenic causes.40 iPSC technology has also been used to study the role of non-coding variants associated with mental diseases.41 Here, we primarily highlight efforts made over the past few years to model the molecular and physiological phenotypes observed in iPSC-derived neurons from patients with the most prevalent neuropsychiatric disorders, namely depression and anxiety disorders, BPD and SCZ (Figure 3).
