Overall, we were interested in replicating and generalizing our prior findings and extending them to other alcohol-related phenotypes. Thus, our goals were twofold: first, we examine whether GRS created from the GWAS of AO-AD in the COGA discovery sample15 is associated with AO-AD in the independent portion of SAGE and in OZ-ALC. Second, we examine whether GRS for AO-AD is associated with other features of alcohol involvement, including age at first intoxication, lifetime maximum drinks in a 24-h period and number of symptoms and diagnosis of alcohol dependence in the SAGE and OZ-ALC datasets.
