genes rather than TMPPE. The lack of replication of this signal in other published GWAS is unfortunate, but unsurprising given that the current study is the largest GWAS of depression in males to date (relative to published GWAS). Ever-increasing sample sizes from international consortia will provide much-needed larger replication datasets for corroborating or dispelling this finding. The lack of replication also highlights the importance of moving towards linking results at the functional level.
