of alcohol on GABAA receptors mediated by neuroactive steroids (Sanna et al., 2004). We also observed that 7-day alcohol exposure significantly increased NMDA receptor subunit mRNA expression, which parallels previous findings in rodent models (Nagy, 2008b, Hu et al., 1996, Follesa and Ticku, 1995). Our results suggest that human iPS-derived neural cells may provide a useful experimental model to examine mechanisms underlying changes in NMDA function and expression in response to acute and chronic alcohol, which remain incompletely understood (Hu et al., 1996, Hanchar et al., 2006).
