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Chunk #54 — Developmental Stress Exposure — Aversive Parental Care Including Maltreatment

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Epigenetic mechanisms in alcohol- and adversity-induced developmental origins of neurobehavioral functioning.
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lysine 9/14 acetylation at the Bdnf exon IV promoter (Blaze et al., 2015). Alterations in both gene specific (i.e. Bdnf) and global methylation have been found in the amygdala and dorsal and ventral subregions of the hippocampus of maltreated animals (Doherty et al., 2016; Roth et al., 2014). Other gene targets of maltreatment include neuropeptide Y and the oxytocin receptor, which have both been found to be altered in the amygdala of adolescent animals (Hill et al., 2014).