The 2019 GWAS9 identified 53 genes across 20 non-APOE loci with a priority score of greater than 5; the 23 genes with the highest score in each locus are presented in table 2. Conditional analysis indicated that there are probably several functional variants in the 8p21.1 and 6p21.1 loci. The 2019 GWAX7 identified 35 genes across 15 non–APOE loci that were implicated in three of the four gene mapping or gene–based analyses used, with 25 genes having further evidence of brain–specific QTL annotations; the 22 genes with the highest evidence in each locus are presented in table 2. Conditional analyses indicated multiple independent association signals in the 2q14.3, 6p21.1, 8p21.1, and 19p13.3 loci. For the APOE locus, eight genes (PVR, TOMM40, BCAM, APOC1, APOC4, CLPTM1, IGSF23, and APOE) were implicated by all four of the gene–mapping or gene–based analyses used. PVR and TOMM40 also have further evidence of brain–specific eQTL and methylation QTLs (mQTLs). Conditional analysis also indicated that there are potentially multiple independent signals in the APOE locus. Pathway analysis in the 2018 and 2019 GWAX7,8 and the 2019
