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Chunk #23 — Results — Coverage of variation in the genes

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Neuropeptide Y receptor genes are associated with alcohol dependence, alcohol withdrawal phenotypes, and cocaine dependence.
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Seventeen SNPs were genotyped across the 31 kb region containing NPY1R and NPY5R, extending 3 kb on the 3’ end of NPY1R. The average r2 of 11 SNPs of the 17 SNPs genotyped on NPY1R/NPY5R with all of the 21 known HapMap SNPs (MAF≥0.10) in the 31 kb region was 0.80; r2 > 0.5 for 81% of the SNPs and r2 > 0.8 for 67% of the SNPs (Table 2). Again, this is the lower bound of coverage because we genotyped 6 additional SNPs that could not be evaluated.