power to detect effects. We re-analysed the data excluding patients to verify that detected effects were not due to disease alone (Extended Data Fig. 5a). The protocols used for testing association with mach2qtl (ref. 34) for studies with unrelated subjects and merlin-offline36 for family-based designs are freely available online (http://enigma.ini.usc.edu/protocols/genetics-protocols/). Full details for the software used at each site are given in Supplementary Table 3.
