Chunk #23 — Findings — Improvements in PLINK 1.9 — Other noteworthy algorithms — Partial sum lookup

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Second-generation PLINK: rising to the challenge of larger and richer datasets.

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Each entry of a weighted genomic distance matrix between pairs of individuals is a sum of per-marker terms. Given PLINK 1 binary data, for any specific marker, there are seven distinct cases at most: Both genotypes are homozygous for the major allele.One is homozygous major, and the other is heterozygous.One is homozygous major, and the other is homozygous minor.Both are heterozygous.One is heterozygous, and the other is homozygous minor.Both are homozygous minor.At least one genotype is missing.