The commonly used bipolar EEG can remove the common reference. However, one should note that bipolar EEG will also remove all signals common to the two channels and not all signals common to the two electrodes are from the reference. Hence, a given bipolar montage will completely miss dipoles with certain locations and tangential orientations. Our simulation results from this patient demonstrated that bipolar EEG usually leads to small correlation, phase-synchrony, and MSC values and, as a result, cannot reflect real large correlation, phase-synchrony, and MSC values between two different channels [see, e.g., Figs. 3(H) and 4(C) and (F)].
