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Chunk #11 — MATERIALS AND METHODS — Phenotypes:

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Genome-wide admixture mapping of DSM-IV alcohol dependence, criterion count, and the self-rating of the effects of ethanol in African American populations.
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The Self-Rating of Effects of Ethanol (SRE) questionnaire is a retrospective, self-report instrument to measure the numbers of standard drinks required to produce four effects of ethanol (Schuckit, Tipp, Smith, Wiesbeck, & Kalmijn, 1997): a) “how many (standard) drinks did it take for you to begin to feel an effect?”; b) “how many drinks did it take for you to feel a bit dizzy or begin to slur your speech?”; c) “how many drinks did it take you to begin to stumble or walk in an uncoordinated manner?”; d) “how many drinks did it take you to pass out or fall asleep when you did not want to?”. The SRE queries drinking at three time points: the first five times using alcohol (SRE-5); the period of heaviest drinking; and the most recent 3 months of consumption (Schuckit, Tipp, et al., 1997). In this study, we used SRE-5 as well as the average scores across the three time points (SRE-T). Individuals who drank >=2 drinks on one occasion were included in the analysis with extreme observations winsorized at the mean plus