paperKB
coga / coga-kb
Help
Sign in

Chunk #11 — METHODS — Statistical Analyses — Association

Source
ANKK1, TTC12, and NCAM1 polymorphisms and heroin dependence: importance of considering drug exposure.
Embedded
yes

Text

to characterize risk (i.e., additive, dominant, or recessive) associated with each of the two SNPs for whom independent signals were found. To estimate their effects in tandem, we coded a risk level variable that was a sum of their effects. In doing so, we verified that risk associated with the alternative routes of obtaining the same risk level (e.g., one copy of the rs877138 minor allele and the rs4492854 major allele versus two copies of the former and none of the latter) did not differ significantly.