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Chunk #68 — Methods — LD score regression analysis

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Genetic identification of cell types underlying brain complex traits yields insights into the etiology of Parkinson's disease.
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We evaluated the effect of varying window sizes and varying the percentage of most specific genes on the schizophrenia cell type associations strength (−log10P). We observed strong Pearson correlations in cell type associations strength (−log10P) across the different percentage and window sizes tested (Figure S28). Our selected window size (100 kb upstream to 100 kb downstream, top 10% most specific genes) had Pearson correlations ranging from 0.96 to 1 with the other window sizes and percentage, indicating that our results are robust to these parameters.