Chunk #44 — Methods — Hi-C

Source

A computational tool (H-MAGMA) for improved prediction of brain-disorder risk genes by incorporating brain chromatin interaction profiles.

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Fetal brain Hi-C data was obtained from the paracentral cortex of three individuals of gestation week (GW) 17–184. Adult brain Hi-C data was obtained from the dorsolateral prefrontal cortex (DLPFC) of three individuals (36, 44, 64 years)3. Neuronal and astrocytic Hi-C data were derived from human induced pluripotent stem cells (hiPSC) obtained from two individuals (15 and 31 years)37.