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Chunk #97 — 6. Comparisons of the selectively bred rat lines — 6.3. Neurochemical differences

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Animal models for medications development targeting alcohol abuse using selectively bred rat lines: neurobiological and pharmacological validity.
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variable. When the number of Ucn1-positive fibers in the lateral septum was assessed, HAD2 rats had greater levels than LAD2 rats, AA rats had greater levels than ANA rats but HAD1 and iP rats did not differ from their low alcohol-consuming counterparts. When comparing the average number of Ucn1-positive cells in the (EWN) of the high alcohol-consuming rat lines the order of magnitude was HAD2>HAD1>iP>AA. When comparing the average number of Ucn1-positive fibers in the lateral septum of the high alcohol-consuming rat lines the order of magnitude was HAD2>HAD1~iP>AA. In general, this study revealed multiple significant differences in the Ucn1 system between and within these rat line-pairs.