The estimated heritability (h2) for the SHAS-E phenotypes ranged from near to zero for "energy" to .28 for "terrible" (see Table 2). The only two phenotypes with significant heritability were talkative and terrible (p < 0.01). Table 2 also gives values for the mean ± S.D. for each of the SHAS-E items as well as the total for this population. As seen in Table 3, endorsing a more intense response on one or more of the following SHAS-E items: dizzy, drunk, high, nausea, talkative, and/or uncomfortable after imbibing 2–3 drinks was significantly associated with having at least one minor allele for 7 SNPs (p < 0.01) in or near the OPRM1 receptor gene. Whereas, for the 118G allele, the most commonly genotyped Asn40Asp polymorphism, there was only a trend for an association with reporting a less intense response to alcohol for the items: dizzy (p < 0.02) and sleepy (p < 0.02).
