Drosophila, and several behavioral responses in rodents (reviewed in Bettinger and Davies, 2014). A top-down approach revealed molecular mechanisms responsible for these behavioral effects. Blocking BK channel transport to the presynaptic plasma membrane alters ethanol-induced locomotor depression in C. elegans (Oh et al., 2017), while Wnt/β-catenin-signaling-dependent trafficking of BK channels out of the membrane contributes to ethanol tolerance at the cellular level (Palacio et al., 2015; Pietrzykowski et al., 2004; Velázquez-Marrero et al., 2016). However, no data have associated these molecular events with ethanol-induced behaviors, including tolerance.
