Chunk #98 — 7.0 Recommendations to Advance Endophenotype Genetics — 7.3 Adequate power to detect individual effects is crucial but almost never attained in existing endophenotype genetic association studies — 7.3.1. Power and sampling schemes in GWAS
variants are important, out of the many hundreds of millions of rare variants that exist. We have argued in this section that GWAS is one recommended way to determine which genomic regions, or loci, contain genetic variants that influence risk for disorder. Determining which variants within a locus are causal is an important step in understanding the genetic basis of the (endo) phenotype. Knowing the causal variants is essential for selection strategies based on genotype but, more importantly, for understanding the biological mechanisms by which the variant influences the (endo) phenotype.
