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Chunk #27 — Methods — Analytical methods — SMA models

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The CHRNA5/A3/B4 gene cluster and tobacco, alcohol, cannabis, inhalants and other substance use initiation: replication and new findings using mixture analyses.
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The survival mixture analysis provides an estimation of the risk to initiate substance use across the observed time. Depending on which model fits best, the risk is more likely constant, proportional, or unconstrained. Furthermore, the analysis provides information regarding the relation between the SNPs and the risk over time, and the relation between the SNPs and the differences between users and long-term survivors.