It is now time for research into the biological basis of cannabis use disorders, through the identification of genetic variants, their interplay with environmental change, and the integration of this knowledge. The possibility that our knowledge fo cannabis use disorders will dramatically improve is perhaps the strongest scientific rationale for pursuing this line of genomic enquiry. However, an additional outcome of this research is the likelihood of enhancing strategies for treatment of cannabis use disorders, and herein lies the tremendous potential for public health. Given the identification of more endogenous cannabinoids, the greatest outcomes of research into genetic vulnerabilities for cannabis use disorders may be a greater understanding of the actions of the endocannabinoids that can be exploited in the treatment of a range of substance related disorders [155,156].
