+1000 bp of the transcription start site, although one differentially methylated region was found just outside the promoter (−2042 bp) of IL-6 (Figure 1). Two differentially methylated regions were found in the enhancer/insulator locus control region (LCR) of the IL-4 and IL-10 loci (Figure 2). Each cytokine gene loci included several other genes, and some of these non-candidates were in fact closer to several differentially methylated regions than the originally short-listed genes. Tables listing all differentially methylated regions associated with aggression for each cell type along with the gene nearest to the region can be found in Spreadsheet S1.
