We have extended the WashU Epigenome Browser10(http://epigenomegateway.wustl.edu) to support multiple types of long-range genome interaction data. The WashU Epigenome Browser was developed for the Roadmap Epigenomics project11 and incorporates ENCODE data. It currently hosts thousands of epigenome and transcriptome datasets for multiple cell types, tissues, individuals, and species. Long-range interaction data and visualization functions are now integrated with existing data and functions of the Browser, enabling investigators to explore epigenomic data in the context of higher order chromosomal domains, and to generate multiple types of intuitive, publication quality figures of interactions. In Figure 1 we display both long-range interaction data and histone modification data of two human cell lines (IMR90 and K562). Two interacting regions are displayed side-by-side and can be explored simultaneously. Hi-C and ChIA-PET capture similar interaction patterns in the two cell lines over these two regions. Interestingly, these two interacting regions exhibit distinct cell type-specific characteristics in their histone modification profiles (Figure 1). These observations are consistent with the hypothesis that chromatin domains are stable across cell types, but can have different epigenetic profiles in different cells.
